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Total trip budget can realistically land around $900 to $1,100 per person if you're smart about it instead of the $1,800-plus you'll hear people throw around

This primary brain injury can be attributed to the activation of secondary injury pathways that include ionic imbalance, oxidative stress, excitotoxicity, mitochondrial dysfunction, inflammation, and BBB breakdown (Dirnagl et al., 1999

They found that certain hormones, like androgen (a male hormone) during the follicular phase and estrogen around ovulation, increased after drinking, and this effect was stronger if someone drank a lot